I'm looking forward to this too, hopefully all the games will be played on schedule and with full crowds.
Watching the European club competitions so far this season, Ireland and France seem to have the best crop of in-form, uninjured players. Id go for Ireland as favourites but they have both France and England away from home and that's a tough ask.
On the other hand, France have both England & Ireland at home so that's much in their favour.
Bookies make it: France 6/4, Ireland 11/4, England 3/1, Wales=Scotland+ 10/1, Italy 1000/1. Cant argue with that.
If anybody is interested & wasn't aware, Guinness organises a free-to-enter fantasy game at
https://fantasy.sixnationsrugby.com/#/game/equipe/me
It's pretty simple to play and (unlike the footy fantasy games) the starters and subs are known in advance of each round of games.
I've got a league set up from last year (just me and a couple of mates) if anybody fancies entering and having a bit of competition.